M2. Chemical and physical manipulations

What is chemical and physical manipulation?

Generally speaking, chemical and physical manipulation consists of the use of substances and/or methods which may alter the integrity and/or validity of urine samples obtained in doping controls.

A typical example of physical manipulation is catheterization – the use of a catheter to remove a doped athlete’s urine and replace it with clean urine. Another example is urine substitution during the sample collection process.

An example of physical manipulation is the use of protease – an enzyme that destroys the proteins of prohibited substances. Adding protease to a urine sample “erases” all evidence of the use of prohibited substances.

Chemical and physical manipulation is an anti-doping rule violation and therefore leads to sanctions.

S0. Non-approved substances

S1. Anabolic agents

S2. Peptide hormones, growth factors and related substances

S3. Beta-2 agonists

S4. Hormone and metabolic modulators

S5. Diuretics and other masking agents

M1. Manipulation of blood and blood components

M3. Gene doping

Substances and methods prohibited in-competition

Substances prohibited in particular sports